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C/N/272. Role of Leptin in Health and Disease

WORDS:
3900
DATE:
2009
PRICE:
39.99 GBP

The paper examines the physiological role of leptin in energy homeostasis considering how abnormalities in leptin signalling may result in disease. The studies that led to the discovery of leptin are reviewed providing a detailed description of the molecular and cellular mechanisms that underlie leptin signalling. The impact of leptin signalling in obesity and diabetes is considered assessing the possibility of pharmacologically targeting the leptin pathway as a treatment for these diseases.

 

KEYWORDS: Leptin, energy homeostasis, obesity, diabetes,

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